Category: News

Smcr8 deficiency disrupts axonal transport-dependent lysosomal function and promotes axonal swellings and gain of toxicity in C9ALS/FTD mouse models. Accepted, Human Molecular Genetics.

Chen Liang1,2, Qiang Shao1, Wei Zhang1, Mei Yang1, Qing Chang1, Rong Chen3, and Jian-Fu Chen1,*

1. Center for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA 90033
2. Department of Cellular Biology, University of Georgia, Athens, GA, 30602
3. Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 100 N. Greene Street, Baltimore,MD 21205, USA

Shao Q#, Yang M#, Liang C, Ma L, Zhang W, Jiang Z, Luo J, Lee JK, Liang C, Chen JF. (2019) C9orf72 and Smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis. Autophagy, in press.

Wei Zhang, Si-Lu Yang, Mei Yang, Stephanie Herrlinger, Qiang Shao, John L. Collar, Edgar Fierro, Yanhong Shi, Aimin Liu, Hui Lu, Bruce E. Herring, Ming-Lei Guo, Shilpa Buch, Zhen Zhao, Jian Xu, Zhipeng Lu, and Jian-Fu Chen (2019) Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors. Nature Communications.

Stephanie Herrlinger, Qiang Shao, Mei Yang, Qing Chang, Yang Liu, Xiaohan Pan, Hang Yin, Li-Wei Xie, and Jian-Fu Chen (2019) Lin28-mediated promotion of protein synthesis is critical for neural progenitor cell maintenance and brain development in mice. Development.

Shao Q, Liang C, Chang Q, Zhang W, Yang M, & Chen J-F (2019) C9orf72 deficiency promotes motor deficits of a C9ALS/FTD mouse model in a dose-dependent manner. Acta Neuropathologica Communications 7:32. doi: 10.1186/s40478-019-0685-7

The Node recently interviewed Chen Lab members about our recent work on African and Asian strains of Zika virus. The text of the interview is available here.

Qiang Shao, Stephanie Herrlinger, Ya-Nan Zhu, Mei Yang, Forrest Goodfellow, Steven L Stice, Xiao-Peng Qi, Melinda A Brindley, and Jian-Fu Chen. The African Zika Virus MR-766 is More Virulent and Causes More Severe Brain Damage than Current Asian Lineage and Dengue Virus. Development 2017, in press.