TheChenLab investigates neuro-craniofacial biology and medicine, focusing on mesenchymal cells and the neurovascular niche. We study diverse mesenchymal cells, such as mesenchymal stem cells (MSCs), fibroblasts, fibrocartilage cells, tendon cells, and their interactions with the neurovascular and lymphatic vessel niche.
Discoveries from our lab are used to advance disease mechanisms and treatment for various clinically relevant pathologies, including craniosynostosis, skull injury, temporomandibular joint (TMJ) degeneration and pain, as well as salivary gland-related xerostomia (dry mouth).
Skull mesenchymal stem cell (MSC)
We uncover the roles of skull mesenchymal stem cells and their niches in craniofacial disorders, revealing lymphatic vessels within bone and new therapeutic targets.
Temporomandibular joint disorders (TMD)
We generate a cellular atlas of the TMJ, define fibroblast–neuron interactions driving arthritis and pain, and advance progenitor-based regenerative strategies for TMD through translational collaboration.
Lymphatic vasculature
By uncovering neuro-lymphatic pathways that regulate fluid balance and pain, we provide new mechanistic insights and therapeutic opportunities for craniosynostosis, migraine, small vessel disease, and dementia.