2024
Zhang W, Zhang M, Ma L, Jariyasakulroj S, Chang Q, Lin Z, Lu Z, Chen JF. (2024) Recapitulating and reversing human brain ribosomopathy defects via the maladaptive integrated stress response. Science Advances. Accepted.
Pei F, Ma L, Guo T, Zhang M, Jing J, Wen Q, Feng J, Lei J, He J, Janečková E, Ho TV, Chen JF, Chai Y. Sensory nerve regulates progenitor cells via FGF-SHH axis in tooth root morphogenesis. Development. 2024 Jan 15;151(2):dev202043. doi: 10.1242/dev.202043. Epub 2024 Jan 11. PMID: 38108472.
2023
Ma L, Wang F, Li Y, Wang J, Chang Q, Du Y, Sadan J, Zhao Z, Fan G, Yao B, Chen JF. (2023) Brain methylome remodeling selectively regulates neuronal activity genes linking to emotional behaviors in mice exposed to maternal immune activation. Nat Commun. 2023 Nov 29;14(1):7829. doi: 10.1038/s41467-023-43497-4. PMID: 38030616; PMCID: PMC10687003
Jariyasakulroj S, Zhang W, Bai J, Zhang M, Lu Z, Chen JF. (2023) Ribosome biogenesis controls cranial suture MSC fate via the complement pathway in mouse and human iPSC models. Stem Cell Reports. 2023 Dec 12;18(12):2370-2385. doi: 10.1016/j.stemcr.2023.10.015. Epub 2023 Nov 16. PMID: 37977145; PMCID: PMC10724072
Ma, L., Chang, Q., Pei, F., Liu, M., Zhang, W., Hong, Y-K., Chai, Y., Chen, JF. Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis, Cell Stem Cell (2023), https://doi.org/10.1016/j.stem.2023.09.012.
Pei F, Ma L, Jing J, Feng J, Yuan Y, Guo T, Han X, Ho T-V, Lei J, He J, Zhang M, Chen J-F, Chai Y. (2023) Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis. Nat Commun 14, 344. https://doi.org/10.1038/s41467-023-35977-4.
2022
Ma L, Liang C, Wang J, Chang Q, Wang Y, Zhang W, Du Y, Sadan J, Chen JF. (2022) Reversing lysosome-ribosome circuit dysregulation mitigates C9FTD/ALS neurodegeneration and behaviors. Human Molecular Genetics, accepted.
Stanton E, Urata M, Chen JF, Chai Y. (2022) The clinical manifestation, molecular mechanisms, and treatment of craniosynostosis. Dis Model Mech. 2022 Apr 1;15(4):dmm049390. doi: 10.1242/dmm.049390. Epub 2022 Apr 22. PMID: 35451466; PMCID: PMC9044212.
2021
Ma L, Wang J, Ge JL, Wang Y, Zhang W, Du YN, Luo J, Li YP, Wang F, Fan GP, Chen R, Yao B, Zhao Z, Guo ML, Kim WK, Chai Y, Chen JF. Reversing neural circuit and behavior deficit in mice exposed to maternal inflammation by Zika virus. EMBO Rep. Aug 4;22(8):e51978 PMID: 34232545
Yu M, Ma L, Yuan Y, Ye X, Montagne A, He J, Ho TV, Wu Y, Zhao, Z, Sta Maria N, Jacob R, Urata M, Wang H, Zlokovic BV, Chen JF, Chai Y. Cranial suture regeneration mitigates skull and neurocognitive defects in craniosynostosis. Cell. Jan 7;184(1):243-256 PMID: 33417861
Zhang MJ, Li KP, Bai JH, Velema W, Yu CQ, Damme RV, Lee W, Corpuz ML, Chen JF, Lu ZP. Optimized photochemistry enables efficient analysis RNA structuromes and interactomes in genetic and infectious diseases. Nature Communications. Apr 20;12(1):2344 PMID: 33879794
Wu Y, Wu H, Zeng J, Pluimer B, Dong S, Xie X, Guo X, Ge T, Liang X, Feng S, Yan Y, Chen JF, Sta Maria N, Ma Q, Gomez-Pinilla F, Zhao Z. Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice. Acta Neuropathol Commun. Apr 23;9(1):74 PMID:33892818
2020
Zhang W, Ma L, Shao Q, Xu J, Lu Z, Zhao Z, Chen R, Chai Y, Chen JF. Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes. Genes Dev. Apr 1;34(7-8):580-587 PMID: 32115408
Shao Q, Yang M, Liang C, Ma L, Zhang W, Jiang ZW, Luo J, Lee JK, Liang CY, Chen JF. c9orf72 and smcr8 mutant mice reveal mTORC1 activation due to impaired lysosomal degradation and exocytosis. Autophagy. Dec 26:1-16. PMID: 31847700
Zeng J, Dong S, Luo Z, Xie X, Fu B, Li P, Liu C, Yang X, Chen Y, Wang X, Liu Z, Wu J, Yan Y, Wang F, Chen JF, Zhang J, Long G, Goldman SA, Li S, Zhao Z, Liang Q. The Zika virus capsid disrupts corticogenesis by suppressing Dicer activity and miRNA biogenesis. Cell Stem Cell. Oct 1;27(4): 618-632. PMID: 32763144
2019
Zhang W, Yang SL, Yang M, Herrlinger S, Shao Q, Collar J, Fierro E, Shi Y, Liu A, Lu H, Herring BE, Guo ML, Buch S, Zhao Z, Xu J, Lu Z, Chen JF. Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors. Nature Communications. 10(1):2612. PMID: 31197141
Herrlinger S, Shao Q, Yang M, Chang Q, Liu Y, Pan X, Yin H, Xie LW, Chen JF. Lin28-mediated promotion of protein synthesis is critical for neural progenitor cell and early brain development. Development. May 28;146(10) PMID: 31064784
Liang C, Shao Q, Zhang W, Yang M, Chang Q, Chen JF. Smcr8 deficiency disrupts axonal transport-dependent lysosomal function and promotes axonal swellings and gain of toxicity in C9ALS/FTD mouse models. Human Molecular Genetics. Dec 1;28(23)3940-3953 PMID: 31625563
Shao Q, Liang C, Chang Q, Zhang W, Yang M, Chen JF. C9orf72 deficiency promotes motor deficits of a C9ALS/FTD mouse model in a dose-dependent manner. Acta Neuropathol Commun. 7(1):32. PMID: 30832726
2018
Herrlinger SA, Shao Q, Ma L, Brindley M, Chen JF. Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult. J Vis Exp. Apr 26;(134). PMID: 29757270
Wang YC, Chuang YH, Shao Q, Chen JF, Chen SY. Brain cytoplasmic RNA 1 suppresses smooth muscle differentiation and vascular development in mice. J Biol Chem. 293(15):5668-5678. PMID: 29467228
Dong K, Guo X, Chen W, Hsu AC, Shao Q, Chen JF, Chen SY. Mesenchyme homeobox 1 mediates transforming growth factor-β (TGF-β)-induced smooth muscle cell differentiation from mouse mesenchymal progenitors. J Biol Chem. 293(22):8712-8719. PMID: 29678882
2017
Shao Q, Herrlinger S, Zhu YN, Yang M, Goodfellow F, Stice SL, Qi XP, Brindley MA, Chen JF. The African Zika virus MR-766 is more virulent and causes more severe brain damage than current Asian lineage and dengue virus. Development. 144(22):4114-4124. PMID: 28993398
2016
Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F, Shiekhattar R, Chen JF. A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. Science Advances. 2(9). PMID: 27617292
Shao Q, Herrlinger S, Yang SL, Lai F, Moore JM, Brindley MA, Chen JF. Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage. Development. 143(22):4127-4136. PMID: 27729407
2015
Yang M, Yang SL, Herrlinger S, Liang C, Dzieciatkowska M, Hansen KC, Desai R, Nagy A, Niswander L, Moss EG, Chen JF. Lin28 promotes proliferative capacity of neural progenitor cells for brain development. Development. 142(9):1616-27. PMID: 25922525
Yang SL, Yang M, Herrlinger S, Liang C, Lai F, Chen JF. MiR-302/367 regulates neural progenitor proliferation, differentiation timing, and survival in neurulation. Developmental Biology. 408(1):140-50. PMID: 26441343
Postdoc publications at UC Denver (2009-2014)
Chen JF, Zhang Y, Wilde J, Hansen KC, Lai F, Niswander L (2014). Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size. Nature Communications. 5:3885. PMID: 24875059
Harmacek L, Watkins-Chow DE, Chen J, Jones KL, Pavan WJ, Salbaum JM, Niswander L (2013). A unique missense allele of BAF155, a core BAF chromatin remodeling complex protein, causes neural tube closure defects in mice. Dev Neurobiol. 74(5):483-97. PMID: 24170322
Chen JF, Lai F, Niswander L (2012). The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes & Development. 26(8): 803-15. PMID: 22508726 (Cover)
Graduate publications at UNC-CH (2004-2009)
Huang ZP, Young Seok H, Zhou B, Chen J, Chen JF, Tao Y, Pu WT, Wang DZ (2012). CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circulation Res. 16;110(6):818-30. PMID: 22343712
Tao Y, Neppl RL, Huang ZP, Chen JF, Tang RH, Cao R, Zhang Y, Jin SW, Wang DZ (2011). The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly. J Cell Biol. Aug 22;194 (4):551-65. PMID: 21859860
Deng Z, Chen JF, Wang DZ (2011). Transgenic overexpression of miR-133a in skeletal muscle. BMC Musculoskeletal Disord. 12(1): 115. PMID: 21615921
Chen JF, Tao Y, Li J, Deng Z, Yan Z, Xiao X, Wang DZ (2010). MicroRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7. J Cell Biol. 190(5):867-79. PMID: 20819939
Huang ZP, Chen JF, Regan JN, Maguire CT, Tang RH, Dong XR, Majesky MW, Wang DZ (2010). Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects. Arterioscler, Thromb, Vasc Biol. 30(12): 2575-86. PMID: 20884876
Chen JF, Callis TE, Wang DZ (2009). microRNAs and muscle disorders. J Cell Sci. 122(Pt1): 13-20. PMID: 19092056
Callis TE, Pandya K, Seok HY, Tang RH, Tatsuguchi M, Huang ZP, Chen JF, Deng Z, Gunn B, Shumate J, Willis MS, Selzman CH, Wang DZ (2009). MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest. 119(9): 2772-2786. PMID: 19726871
Chen JF, Murchison EP, Tang R, Callis TE, Tatsuguchi M, Deng Z, Rojas M, Hammond SM, Schneider MD, Selzman CH, Meissner G, Patterson C, Hannon GJ, Wang DZ (2008). Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc of Natl Acad Sci. 12; 105(6): 2111-6. PMID: 18256189
Chen JF, Wang S, Wu Q, Cao D, Nguyen T, Chen Y, Wang DZ (2008). Myocardin marks the earliest cardiac gene expression and plays an important role in heart development. Anat Rec. 291(10): 1200-11. PMID: 18780304
Callis TE, Deng Z, Chen JF, Wang DZ (2008). Muscling through the microRNA world. Exp Biol Med (Maywood). 233(2):131-8. PMID: 18222968
Callis TE, Chen JF, Wang DZ (2007). MicroRNAs in skeletal and cardiac muscle development. DNA and Cell Biol. 26(4):219-25. PMID: 17465888
Tatsuguchi M, Seok HY, Callis TE, Thomson JM, Chen JF, Newman M, Rojas M, Hammond SM, Wang DZ (2007). Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J Mol Cell Cardiol. 42(6): 1137-41. PMID: 17498736
Chen JF, Mandel EM, Thomson JM, Wu Q, Callis TE, Hammond SM, Conlon FL, Wang DZ (2006). The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nature Genetics. 38(2): 228-33. PMID: 16380711
Shan L, Oh HS, Chen JF, Guo M, Zhou J, Alfano JR, Collmer A, Jia X, Tang X (2004). The HopPtoF locus of Pseudomonas syringae pv. tomato DC3000 encodes a type III chaperone and a cognate effector. Mol Plant Microbe Interact. 17(5):447-55. PMID:15141948